View Full Version : Melanoma and the Greying Horse

25th April 2011, 03:37 PM
Melanoma and the Greying Horse

42 pages
Published: 1 Jan 1997
Author(s): RH Sutton, CT Cloeman
ISBN: 0-642-54026-8

The grey horse melanoma is a widely recognized but poorly understood condition. Its importance lies in its high prevalence, as a cause of rejection of grey horses for slaughter at export abattoirs, and as a potential model for pigment cell disorders and malignancies in other species (including people). Grey horses can be born any colour but with age there is a dilution of coat colour to grey and then white. Heavily pigmented tumours develop in many of these animals, apparently concurrent with the dilution in coat colour. The mechanism which underlies the progressive failure of hair follicles to produce pigment is unknown. Although among the most common of equine tumours, the exact nature of the grey horse melanoma has been the subject of debate since the turn of the century. Some argue that it is indeed a true malignancy. Other scientists have suggested that it may be a storage disorder following an abnormality of pigment metabolism; as the hair follicles lose their ability to produce pigment or pass it on to the growing hair, pigment is stored away in slowly enlarging masses. Yet another argument is that it is a variant of a type of benign mole seen in people, the blue naevus. There is evidence to support and undermine each theory but, in truth, we have progressed little since Lord McFadyean’s description of the condition in 1933. With recent advances in the study of mammalian pigmentation genetics, there may be new opportunities to understand the steps leading to the development of this condition. As a requisite first step, information needs to be gathered on the basic biology of the tumour in grey horses; are horses with different patterns of coat colour dilution at different levels of risk of contracting the disease, is there a sex predilection, are other anomalies of pigmentation such as vitiligo involved, what are the anatomical features of the tumour at both light and electron microscopic levels, and what ultrastructural changes can be determined in the hair follicles of horses as their coats lose their colour? These are the questions addressed in the present study.