Results 1 to 7 of 7

Thread: Alfaxalone

  1. #1
    scyt87's Avatar
    New Member

    Status
    Offline
    Join Date
    Oct 2010
    Work
    Veterinary Student
    Country
    Singapore
    Gender
    Male
    Total Posts
    7
    Rep Power
    0
    Total thanks received
    18
    Thanks for this post
    5
    Veterinary Student I'm from Singapore

    Default Alfaxalone

    Good day! I've searched the web for alflaxalone and its effect on liver diseased patients but to no avail. Any help would be appreciated. Can alflaxalone be administered in patients with severe liver dysfunction? Thanks.
    Reply With Quote Reply With Quote
    Thanks

  2. Who Said Thanks:


  3. #2
    Danchou's Avatar
    Silver Member


    Status
    Offline
    Join Date
    Nov 2010
    Work
    Veterinary Student
    Country
    Brazil
    Gender
    Male
    Total Posts
    114
    Rep Power
    423
    Total thanks received
    3,553
    Thanks for this post
    35
    Veterinary Student I'm from Brazil

    Default

    Alfaxalone (INN, also known as alphaxalone or alphaxolone) is a neurosteroidgeneral anaesthetic. It is one of the constituents of althesin. It is used in veterinary practice under the tradename Alfaxan. It is licensed for use in both dogs and cats. Unlike some of its predecessors Alfaxalone is not associated with histamine release and anaphylaxis. The primary mechanism for the anaesthetic action of alfaxalone is modulation of neuronal cell membrane chloride ion transport (1), induced by binding of alfaxalone to GABAA cell surface receptors. It has also been shown that Alfaxalone binds to a different region of this receptor than the benzodiazipines (2). Alfaxalone is metabolised rapidly in the liver. Alfaxalone has a very short plasma elimination half-life in dogs and cats.

    http://en.wikipedia.org/wiki/Alfaxalone


    Here a rapid guide about the drug in VASG
    Hidden contents (Our Amazon affiliate links)
    You must click 'Thank You' before you can see the data contained here. You can purchase this item from Amazon with discount through our amazon affiliate link.
    BUT You DONOT have sufficient rights to see the hidden data contained here.
    Please Register to see contents.

    Rapidly metabolised in the liver... it should or not be a bad thing for the liver... let's start a Brain Storm here.


    Hope you enjoy

    Last edited by Danchou; 23rd August 2011 at 02:50 AM.
    Reply With Quote Reply With Quote
    Thanks

  4. #3
    kib0rg's Avatar
    New Member

    Status
    Offline
    Join Date
    Oct 2011
    Work
    Pet Owner
    Country
    Antilles
    Gender
    Male
    Total Posts
    4
    Rep Power
    0
    Total thanks received
    7
    Thanks for this post
    0
    Pet Owner I'm from Antilles

    Default

    thx for this topic
    Reply With Quote Reply With Quote
    Thanks

  5. #4
    Danchou's Avatar
    Silver Member


    Status
    Offline
    Join Date
    Nov 2010
    Work
    Veterinary Student
    Country
    Brazil
    Gender
    Male
    Total Posts
    114
    Rep Power
    423
    Total thanks received
    3,553
    Thanks for this post
    0
    Veterinary Student I'm from Brazil

    Default

    And you can always use Inhalant anesthesia dude... Isoflurane and Sevoflurane > lungs working...with care in patients with shock, inhalant anesthesia is a friend of the liver.
    Reply With Quote Reply With Quote
    Thanks

  6. #5
    scyt87's Avatar
    New Member

    Status
    Offline
    Join Date
    Oct 2010
    Work
    Veterinary Student
    Country
    Singapore
    Gender
    Male
    Total Posts
    7
    Rep Power
    0
    Total thanks received
    18
    Thanks for this post
    0
    Veterinary Student I'm from Singapore

    Default Re: Alfaxalone

    I suppose alfaxalone is more of an induction drug. And yes isoflurane is definitely a first choice maintenance drug.
    Reply With Quote Reply With Quote
    Thanks

  7. #6
    Ayrial's Avatar
    Banned

    Status
    Offline
    Join Date
    May 2012
    Work
    Veterinary Student
    Country
    Australia
    Gender
    Female
    Total Posts
    5
    Rep Power
    0
    Total thanks received
    10
    Thanks for this post
    0
    Veterinary Student I'm from Australia

    Default Re: Alfaxalone

    Thanks for this thread I was wondering about this topic also
    Reply With Quote Reply With Quote
    Thanks

  8. #7
    anthonysmithglo's Avatar
    New Member

    Status
    Offline
    Join Date
    Oct 2017
    Work
    Veterinary Student
    Country
    Gibraltar
    Gender
    Male
    Total Posts
    15
    Rep Power
    0
    Total thanks received
    7
    Thanks for this post
    0
    Veterinary Student I'm from Gibraltar
    Reply With Quote Reply With Quote
    Thanks

Similar Threads

  1. Using Alfaxalone as an Anaesthetic in Horses
    By and1991 in forum Equine eBooks
    Replies: 0
    Last Post: 10th October 2011, 11:49 AM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •