Mucosal and Body Surface Defences
by Andrew E. Williams
Edition: 1st., 2012
The vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology.
After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokines, before covering the workings of the mucosal immune system. It continues by examining immunity against the four major groups of pathogens - viruses, bacteria, fungi and parasites, and concludes by looking at disorders of the immune system, mucosal tumour immunology and the process of vaccination.
- A fresh, new approach to the subject focusing on mucosal and body surfaces.
- Describes the mucosal immune systems of the gastrointestinal, respiratory and urogenital tracts, as well as the skin.
- Details the important roles of cytokines and chemokines in an immune response.
- Separate chapters devoted to immunity against viruses, bacteria, fungi and parasites.
- Includes chapter summaries, boxes with topics of special interest and an extensive glossary.
- Clearly written and well- illustrated in full colour throughout.
Students across a range of disciplines, including biology, biochemistry, biomedicine, medicine and veterinary sciences, will find this book invaluable, both as an introduction to basic immunology and as a guide to mucosal immune defence mechanisms.
- Covers the basic aspects of immunology with a particular focus on the mucosa, the largest immune organ in the body. The main site of pathogen entry is through mucosal tissues yet this very important area of immunology has never been covered fully in any other text.
- Provides a step-by-step explanation of how the immune system clears pathogens from the host from the moment the pathogen enters the host to the moment it is destroyed by the immune system. Other texts concentrate on basic immunology/development of the immune system and therefore neglect the fundamental role of the immune system, which is to fight infections.
- Modern, and exciting topics of immunology are detailed throughout each chapter. Most texts fail to enlighten the student about up to date topics that are at the cutting edge of immunology. This book readdresses the balance by providing the reader with the latest information about modern immunology.
- Covers certain topics of modern immunology that other texts have not covered. For example, a chapter devoted to the immunology and biology of ‘mucosal immunity’, ‘cytokines and chemokines’ and ‘homeostasis and immune surveillance’ is included. Although these are vital areas of modern immunology they have received little attention from many standard texts.
- Each chapter contains boxed areas of text containing for example case studies, techniques or recent developments worthy of the public’s attention.
- The book includes an associated website containing a range of support material for lecturers including a complete set of the figures included within the text, and printable lecture handouts.