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Thread: Chemical Carcinogenesis

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    Default Chemical Carcinogenesis

    Chemical Carcinogenesis
    by Trevor M. Penning




    Pages: 440
    Publisher: --
    Edition: 1st., 2011
    Language: English
    ISBN: 978-1617379956

    Description

    This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
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    Default Re: Chemical Carcinogenesis

    Chemical Carcinogenesis
    2011





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