- Hardcover: 428 pages
- Publisher: -; 1 edition (April 12, 2010)
- Language: English
- ISBN-10: 0470424745
- ISBN-13: 978-0470424742
- Product Dimensions: 10 x 7 x 1 inches
This book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data.
- A "how to" of bacterial population genetics, which covers an extremely large range of organisms
- Expanding area of science due to high-throughput genome sequencing of bacterial pathogens
- Covers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology
- Detailed treatment of statistical methods
Covers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology
Population genetics is concerned with the causes and effects of genetic variation. While many books give detailed treatments of modern population genetics, for those who study bacterial pathogens, one often has to ask "How does this apply to bacteria?" What has been lacking is a book that describes the fate of genetic variation in bacterial populations and shows how one can generate and analyze bacterial genetic data from a population genetics perspective.
Bacterial Population Genetics in Infectious Disease fills this need, serving as an authoritative primer on the major concepts and methods of an extremely broad range of organisms. The first section provides perspective on the genetic and population processes that shape genetic variation in bacterial populations, as well as the statistical methods of analysis of bacterial genetic data that provide a basis for sound inference. The second section provides detailed reviews on selected important human pathogens, which illustrate the use of analytical techniques and particular evolutionary processes. Bacterial Population Genetics in Infectious Disease is a must for students and professionals that work in the intersecting fields of genetics, microbiology, infectious diseases, epidemiology, and evolutionary biology.