Animal Models for Assessing Countermeasures to Bioterrorism Agents
by National Research Council

Pages: 153
Publisher: NAS Press
Edition: 2011
Language: English
ISBN: 9780309219099
Format: PDF
Size: 3 MB


Animal Models for Assessing Countermeasures This issue evaluates how well the existing TMT-employed or candidate animal models reflect the pathophysiology, clinical picture, and treatment of human disease as related to the agents of interest. The report also evaluates alternatives to the use of animal models based on the premise of the Three Rs.

The report addresses the process and/or feasibility of developing new animal models for critical biodefense research, placing emphasis on the need for a robust and expeditious validation process in terms of the FDA's Animal Rule.


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