Readings in Advanced Pharmacokinetics - Theory, Methods and Applications
by Ayman Noreddin
InTech, April, 2012
This book covers up to date information and practical topics related to the study of drug pharmacokinetics in humans and in animals. The book is designed to offer scientists, clinicians and researchers a choice to logically build their knowledge in pharmacokinetics from basic concepts to advanced applications.
This book is organized into two sections.
The first section discusses advanced theories that include a wide range of topics; from bioequivalence studies, pharmacogenomics in relation to pharmacokinetics, computer based simulation concepts to drug interactions of herbal medicines and veterinary pharmacokinetics.
The second section advances theory to practice offering several examples of methods and applications in advanced pharmacokinetics.
Section 1 Advanced Concepts
1 Bioequivalence Studies
2 Computer Simulations as a Tool for Optimizing Bioequivalence Trials
3 Evaluation of Percutaneous Drug Permeation Using a Lateral Sectioning Approach
4 Pharmacogenomics Dictate Pharmacokinetics: Polymorphisms in Drug-Metabolizing Enzymes and Drug-Transporters
5 Genetic Variation in Drug Disposition
6 Application of Pharmacokinetics/Pharmacodynamics (PK/PD) in Designing Effective Antibiotic Treatment Regimens
7 Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process
8 Pharmacokinetics of Antimicrobials in Food Producing Animals
9 Comparative Veterinary Pharmacokinetics
Section 2 Methods and Applications
10 Observer-Based Strategies for Anesthesia Drug Concentration Estimation
11 Optimal Pharmacokinetics of Cyclosporine and Tacrolimus Based Relationship Among AUC, Trough and Peak Concentration
12 Pharmacokinetics and Metabolized Caroteniods in Liver of Single Dose Administration in Fancy Carp (Cyprinus carpio)
13 Correlation of in vitro Dissolution Profiles with in vivo Pharmacokinetic Parameters of Some Commercial Brands of Aspirin Tablets Marketed in Nigeria
14 Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia
15 Role of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs
16 Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents
17 Pharmacokinetic (PK) and Pharmacodynamic Profiles of Artemisinin Derivatives Influence Drug Neurotoxicity in Animals
18 One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine