By Robert Brown and Uta Böger-Brown

  • Hardcover: 238 pages
  • Publisher: Humana Press; 1st edition (April 15, 1999)
  • Language: English
  • ISBN-10: 0896036030
  • ISBN-13: 978-0896036031
  • Book Description

    Publication Date: April 15, 1999 | ISBN-10: 0896036030 | ISBN-13: 978-0896036031 | Edition: 1st
    Leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. The protocols contain detailed instructions and extensive troubleshooting tips that allow researchers effectively to study a wide variety of drug resistance mechanisms, including aspects of drug-induced cell death, drug uptake/efflux, drug metabolism, and DNA repair. Each method is designed to help identify the correlation between molecular and biochemical data and the clinical responses of the patient. Cytotoxic Drug Resistance Mechanisms illuminates all the clinically relevant mechanisms used as markers of the biological response to anticancer biotherapeutics today.

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