Molecular Monitoring of Equine Joint Homeostasis
by Grauw, J.C
EDITION: First, (2010)
LANGUAGE: English & Ducth
Chronic joint disorders are a major cause of impaired mobility and loss of quality of life in both humans and horses. Regardless of the primary insult, any joint disorder is characterized by an upset in normal joint homeostasis, the balance between tissue anabolism and catabolism that is normally maintained by resident articular cells. This upset is often fuelled by a local inflammatory response in the synovial membrane and the articular cartilage. Our current understanding of the pathogenesis of chronic joint disease is hampered by a lack of tools for the accurate assessment of joint homeostasis. This thesis explores the analysis of direct (cartilage components) and indirect biomarkers (paracrine effectors like cytokines, inflammatory mediators and catabolic enzymes) in synovial fluid from horses with naturally occurring and experimentally induced disease as a means to study real-time changes in the intra-articular environment.