Endocrine-Disrupting Chemicals An Endocrine
Diamanti-Kandarakis E et al.

Publisher:The Endocrine Society
Language: English

An endocrine-disrupting compound was defined by the
U.S. Environmental Protection Agency (EPA) as “an
exogenous agent that interferes with synthesis, secretion,
transport, metabolism, binding action, or elimination of
natural blood-borne hormones that are present in the
body and are responsible for homeostasis, reproduction,
and developmental process.” Our understanding of the
mechanisms by which endocrine disruptors exert their effect
has grown. Endocrine-disrupting chemicals (EDCs)
were originally thought to exert actions primarily through
nuclear hormone receptors, including estrogen receptors
(ERs), androgen receptors (ARs), progesterone receptors,
thyroid receptors (TRs), and retinoid receptors, among

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