Pharmacokinetics and Metabolism in Drug Design
by Douglas A. Smith (Author), Charlotte Allerton (Author), Amit S. Kalgutkar (Author), Han Waterbeemd (Author), Don K. Walker (Author), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

  • Hardcover: 268 pages
  • Publisher: --
  • Edition: May 22, 2012
  • Language: English
  • ISBN-10: 3527329544
  • ISBN-13: 978-3527329540

in this new edition of a bestseller, all the contents have been brought up to date by addressing current standards and best practices in the assessment
and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new
topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential
problems created by their transformation into toxic byproducts. Uniquely comprehensive, the book relates physicochemistry and chemical structure
to pharmacokinetic properties and ultimately drug efficacy and safety.While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and
related subjects.
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