Improving the Utility and Translation of Animal Models for Nervous System Disorders
by Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt
Forum on Neuroscience and Nervous System Disorders; Board on Health Sciences Policy; Institute of Medicine

Pages: 110
Publisher: --
Edition: 1st., 2013
Language: English
ISBN-10: 0-309-26633-5
ISBN-13: 978-0-309-26633-8


This issue discusses potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus is to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected.

The objectives are: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models.
The issue also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

1 Introduction and Overview
2 Evaluation of Current Animal Models
3 Translation from Animal Models to the Clinic: Case Examples from Neuroscience Research
4 Perspectives on Standardization
5 Perspectives on Corresponding Animal and Clinical Endpoints
6 Addressing the Translational Disconnect
7 Summary of Workshop Topics
A: References
B: Workshop Agenda
C: Registered Attendees

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