by Bruce M. Altevogt, Diane E. Pankevich, Marilee K. Shelton-Davenport, Jeffrey P. Kahn, Committee on the Use of Chimpanzees in Biomedical and Behavioral Research

  • Paperback: 200 pages
  • Publisher: 1 edition (December 5, 2011)
  • Language: English
  • ISBN-10: 0309220394
  • ISBN-13: 978-0309220392

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Table of Contents

Study Background and Context 9
Origin of Study and Committee Statement of Task 12
Ethical Considerations 14
Methods and Organization of the Report 15
International Policies Guiding Chimpanzee Use 16
Summary of Chimpanzee Research 20
Analysis of Federally Supported Research 20
Analysis of Private-Sector Supported Research 23
Criteria That Guide the Current Use of Chimpanzees 25
Principles Guiding the Use of Chimpanzees in Research 26
Ethologically Appropriate Physical and Social Environments 27
Criteria to Assess the Necessity of the Chimpanzee for Biomedical Research 28
Criteria for Use of the Chimpanzee in Comparative Genomics and Behavioral Research 33
Reviewing the Necessity of Current Chimpanzee Research 35
Monoclonal Antibodies 36
Development of Chimpanzee Monoclonal Antibodies 37
Safety Testing of Monoclonal Antibody Therapies 38
Respiratory Syncytial Virus 42
HCV Antiviral Drugs 47
Therapeutic HCV Vaccine 50
Prophylactic HCV Vaccine 52
Comparative Genomics 55
Altruism 59
Cognition 62
Future Use of Chimpanzees in Biomedical and Behavioral Research 64
Conclusions and Recommendations 66

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