The Pulmonary Epithelium in Health and Disease
by David Proud
Edition: 1st., 2008
The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. The traditional view of the epithelium as predominantly a physical barrier that also plays a role in ion and water transport has been supplanted by one in which the epithelium is now also considered to be a central regulator of airway inflammation, structure and function. In light of the dramatic changes in our awareness of the complexity of epithelial cell functions, it seemed particularly timely to produce a book to comprehensively address our current understanding of epithelial cell biology. In particular, I wished to focus not only on the epithelium as a regulator of normal airway function, but also to highlight the important roles of the epithelium in host defense, and the contributions of aberrant epithelial biology to the pathogenesis of inflammatory airway diseases.