Antiparasitic and Antibacterial Drug Discovery
by Paul Selzer
Edition: 1st., 2009
It is ironic that three decades ago infectious diseases were viewed as a problem of the past. Malaria and tuberculosis were going to be eradicated, effective vaccines were available for major childhood infections, and an armamentarium of antibiotics was available for common community and hospital-acquired infections. Young physicians were advised not to enter infectious disease specialties because theywere becoming irrelevant.
This publication provides a window on new approaches to drug discovery and development targeting infectious diseases. Fortunately, technology and training in new methodologies of drug discovery have expanded rapidly in the past 10 years. The challenge is how to effectively apply this technology to the thorny problems of global infections and to maintain a drug development pipeline for infectious diseases in light of the immense cost now associated with bringing new drugs to market.
Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.
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