Bone and Osteoarthritis
Topics in Bone Biology
by Felix Brooner

Pages: 220
Publisher: --
Edition: 1st., Vol. 4, 2007
Language: English
ISBN: 978-1-846285134


Osteoarthritis (OA) is a progressive and debilitating disease that affects some two thirds of people older than 65 years. Yet how the disease arises and what cellular and molecular changes the cartilage cells undergo in the
course of the disease is not well understood. In recent years, bone and bone changes have been invoked as causing or contributing to cartilage destruction. Moreover, clinical care of osteoarthritic patients often falls on orthopaedic surgeons, as when an arthritic hip needs replacement. It therefore seemed logical for the series Topics in Bone Biology to devote a volume to this disease and its relationship to bone and bone metabolism,particularly because many matrix molecules and signaling pathways are common to both cartilage and bone.

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