Bone and Cancer
( Topics in Bone Biology )
by Felix Brooner

Pages: 273
Publisher: --
Edition: 1st., Vol. 5, 2009
Language: English
ISBN: 978-1-848820180


Skeletal cancers may originate in bone as primary tumors, or arrive there as a consequence of the metastatic dissemination of cancer cells from distant sites, giving rise to secondary or tertiary tumors. Progression of malignant cancers in bone is fostered by the multipotential bone marrow stromal cells and the complex cellular milieu to which they give rise, including osteoblasts, osteoclasts, hematopoietic stem cells, bone marrow endothelial cells, and their precursors. Changes in genotype and phenotype enhance tumorigenicity of cancer cells in bone, as they adapt to
and remodel the bone marrow microenvironment.

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