Recent Advances in the Field of Urinary Tract Infections
by Thomas Nelius
Edition: July 2013
Urinary tract infections (UTI) continue to be under the most common bacterial infections worldwide. Diagnostic and treatment have substantial financial burden on society. In the USA, UTIs are responsible for more than 7 million physician visits annually and about 15% of all community-prescribed antibiotics in the USA are dispensed for UTIs. About 50% of women will experience at least one UTI episode during lifetime, about 1 million emergency department visits due to UTI in the USA alone, resulting in more than 100 000 hospital admissions annually, most often for pyelonephritis. Moreover, UTIs are also the leading cause of hospital-acquired infections, accounting for approximately 40% of all such cases. The majority of these cases are catheter-associated. Therefore, nosocomial UTIs comprise perhaps the largest institutional reservoir for nosocomial antibiotic-resistant pathogens. Beside the economic impact, UTIs affect also significantly the quality of life of the affected population. The aim of this book is to highlight problematic aspects and recent advances in the field of UTIs.
The book is divided in three parts.
The first part covers issues regarding catheter-associated UTIs including prevention, problems in developing countries and the role of bacterial biofilms.
In the second part deals with potential new diagnostic developments for pediatric related UTIs. This includes new concepts regarding dysfunctional voiding and new anatomical aspects of the vesico-ureteral junction.
Genetic factors underlying susceptibility upper UTIs and potential immune-based treatment strategies are discussed in the third part of the book.
Section 1 Management of Catheter-Associated Urinary Tract Infections
1 Prevention of Urinary Tract Infections in the Outpatient and Inpatient Settings
2 Prevention of Catheter-Associated Urinary Tract Infections
3 Problem of Catheter Associated Urinary Tract Infections in Sub-Saharan Africa
4 Role of Bacterial Biofilms in Catheter-Associated Urinary Tract Infections (CAUTI) and Strategies for Their Control
Section 2 New Aspects in Pediatric Urinary Tract Infections
5 Developments Regarding Dysfunctional Voiding and Urinary Tract Infections in Children
6 Functional Anatomy of the Vesicoureteric Junction: Implication on the Management ofVUR/ UTI
Section 3 Genetical and Immunological Implications for Urinary Tract Infections
7 Genetic Factors Underlying Susceptibility to Acute Pyelonephritis and Post-infectious Renal Damage
8 Immune-Based Treatment Strategies for Patients with Recurrent Urinary Tract Infections - Where Are We?