Molecular Routes to Drug Discovery
by Timo Jäger, Oliver Koch, and Leopold Flohé
Edition: 1st., 2013
The kinetoplastid diseases – sleeping sickness, the leishmaniases, and Chagas disease – are “neglected diseases of poverty,” afflicting millions of people and collectively responsible for over 100 000 deaths per annum. No vaccines are available and current insect vector control methods and other public health measures are insufficient to eliminate them. The currently available drug therapies are far from satisfactory due to issues such as poor efficacy, toxicity, the need for hospitalization,the requirement for prolonged parenteral treatment, and high cost. This book is a
timely attempt to address some of these unmet medical needs.
This is the first resource to provide researchers in academia and industry with an urgently needed update summarizing the current knowledge and possibilities for drug intervention against Trypanosomatides all in one volume. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.
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