Animal Models of Acute Neurological Injuries II, Vol. 1
Injury and Mechanistic Assessments
by Jun Chen
Edition: 2nd., Vol. 1, 2012
Serie: Spr*nger Protocols Handbooks
Our fi rst book, entitled Animal Models of Acute Neurological Injuries, we constructed a benchwork manual for the most commonly used animal models of acute neurological injuries, including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain, and spinal cord injuries. Since its publication, the book has been well received by both clinical and basic researchers due to its practicality. Since the animal models for acute neurological injuries are in place, our next goal, i.e., the goal of these books, was to construct chapters on assessing these disorders from cellsand molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.
The layout of these books is disease/disorder oriented, which encapsulates several parts, including sections on global cerebral ischemia, focal cerebral ischemia, neonatal hypoxia–ischemia, subarachnoid hemorrhage, cerebral vasospasm, intracerebral hemorrhage, traumatic brain injury, traumatic spinal cord injury, and general assessments. Each part includes coverage of morphological, physiological, biochemical, neurobehavioral, and neuroimaging assessments. In general, each begins with an introductory discussion on the availability and selection of specifi c assessments for specifi c injury models as well as their pros and cons. In some chapters, the assessments are divided according to levels of importance into “recommended methods” that are well established and most extensively used, or “alternative methods” that depict less extensively used assessments that have their own utility.