Marek's Disease
Edited by K. Hirai

Series: Current Topics in Microbiology and Immunology (Book 255)
Pages: 296
Publisher: ---
Edition: 1st ed., 2001
Language: English
ISBN-10: 3642632173
ISBN-13: 978-3642632174


Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. This serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses.
This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology,and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases
Front Matter....Pages I-X
The History and Biology of Marek’s Disease Virus....Pages 1-24
Pathogenesis of Marek’s Disease Virus Infection....Pages 25-55
Protective Efficacy of Marek’s Disease Vaccines....Pages 57-90
Immune Responses to Marek’s Disease Virus Infection....Pages 91-120
Genetic Resistance to Marek’s Disease....Pages 121-141
The Genomic Structure of Marek’s Disease Virus....Pages 143-158
Protein-Coding Content of the Sequence of Marek’s Disease Virus Serotype 1....Pages 159-190
A Complete Genomic DNA Sequence of Marek’s Disease Virus Type 2, Strain HPRS24....Pages 191-221
Marek’s Disease Virus Latency....Pages 223-243
Meq: An MDV-Specific bZIP Transactivator with Transforming Properties....Pages 245-260
Polyvalent Recombinant Marek’s Disease Virus Vaccine Against Poultry Diseases....Pages 261-287
Back Matter....Pages 289-294

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