Joint FAO/WHO Expert Committee on
Food Additives

This report represents the conclusions of a Joint FAO/WHO
Expert Committee convened to evaluate the safety of residues
of certain veterinary drugs in food and to recommend maximum
levels for such residues in food.
The first part of the report considers general principles
regarding the evaluation of veterinary drugs within the terms of
reference of JECFA, including compounds without an ADI or
MRL; recommendations on principles and methods in derivation
of MRLs, including a new procedure for estimating chronic
dietary intakes; the use of a spreadsheet-based procedure for
the statistical evaluation of residue depletion data; a revised
approach for the derivation of microbiological ADIs; and the
Committee’s review of and comments on documents provided
by the Codex Committee on Residues of Veterinary Drugs.
Summaries follow of the Committee’s evaluations of
toxicological and residue data on a variety of veterinary drugs:
three antimicrobial agents (colistin, erythromycin, flumequine),
two production aids (melengestrol acetate, ractopamine
hydrochloride), an insecticide (trichlorfon (metrifonate)) and an
anthelminthic (triclabendazole). In addition, the attempt by the
Committee to use tylosin as an example to investigate if
evaluations are possible based on published data in the
absence of data submissions from sponsors is described.
Annexed to the report is a summary of the Committee’s
recommendations on these drugs, including acceptable daily
intakes and proposed maximum residue limits.

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