Antibiotics as Anti-Inflammatory and Immunomodulatory Agents
Antibiotics as Anti-Inflammatory and Immunomodulatory Agents Summary:</STRONG>
Birkhauser | ISBN: 3764359250 | 2005-02-01 | PDF | 275 Pages | 1.77 Mb
Basic research Kazuhiro Tateda et al. Figure 2 Changes of LPS of P. aeruginosa grown in agar with sub-MICs of macrolide antibiotics. Lane 4: azithromycin 4 g/ml. Consequences on the bactericidal activity of phagocytes The possibility that antibiotic-induced stimulation of oxidant production by phagocytes results in increased bactericidal activity has rarely been investigated: for instance, the enhancement of bacterial killing by cefotaxime-treated PMN in vitro was linked to the pro-oxidative effect of this drug 3 . The cephalosporin cefodizime does not modify the phagocyte oxidative burst in vitro, but restores various phagocytic functions in immunocompromised patients ex vivo: in particular, in chronic hemodialysis patients, with a depressed oxidative response, as assessed by hexosemonophosphate shunt activity, cefodizime given for 10 days, significantly increased this phagocytic response compared to cotrimoxazole and placebo treatment 55 . Similarly, 30 patients with severe bacterial infections were treated with cefodizime or ceftriaxone and the effect of cefodizime and ceftriaxone on the phagocytic capacity and generation of reactive oxygen intermediates after phagocytosis by granulocytes was assessed prior to, during, and after therapy. No reports are available on the consequences of prophylactic administration of cefodizime in patients at risk of infections.