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Thread: Molecular Diagnostics of Infectious Diseases 2010

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    Thumbs up Molecular Diagnostics of Infectious Diseases 2010

    "Molecular Diagnostics of Infectious Diseases"
    Harald Kessler



    Publisher: De Gruyter 2010
    ISBN: 3110214857
    Pages: 250 pages
    Format: PDF
    Size: 1,2 MB

    Description

    Molecular diagnostics has become one of the dominant platforms in clinical laboratory
    medicine. In recent years, the advent of molecular methods has revolutionized the
    evaluation of patients with presumed infectious diseases. Molecular methods not only
    evaluate patients with infectious diseases but also contribute to the use of therapeutic
    modalities in their treatment and cure.
    Molecular diagnostics based on the direct detection of specific genetic material
    in a specimen through nucleic acid amplification techniques (NATs) has largely
    replaced antigen testing by immunoassays and become the leading technology. The
    new molecular test systems are more specific and sensitive. They are able to detect
    the presence of a pathogen faster than immunoassays. Furthermore, NATs provide the
    possibility for detection of genetic variations allowing for further characterization of
    pathogens including geno- and subtypes and drug-resistant variants.
    Today, improved molecular diagnostics instrumentation automates many of the
    sample preparation and assay steps that were formerly labor intensive. Robust chemistries
    allow continual launch of new molecular assays with the majority of them being
    CE-marked and/or FDA-cleared. Consequently, molecular diagnostics is indicated in
    many areas of healthcare including infectious diseases, hematology/oncology, genetic
    disorders and forensic medicine with molecular diagnostics of infectious diseases
    making up the major part of the molecular in vitro diagnostics (IVD) market.
    This book is intended to give a timely overview of molecular diagnostics of infectious
    diseases. In the general section (chapters 1–6), preanalytical, analytical and postanalytical
    issues are discussed. Furthermore, special attention is drawn to quality assurance/
    quality control issues. In the specialized section (chapters 7–13), NATs for detection of
    pathogens producing infectious diseases are discussed in detail. Each chapter focuses
    on infectious diseases targeting a specific body tract or system. In all, this book can be
    used as a starting point to evaluate which molecular method, test system, or instrument
    may be considered or chosen for diagnostics of infectious diseases.
    Molecular Diagnostics of Infectious Diseases tries to cover the whole field and provides
    the utmost timely content. However, the reader should consider that this field is still
    changing rapidly. Suggestions for further improvements to be considered in a future edition
    are highly appreciated. Please contact the editor at .
    Harald H. Kessler

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