Retroviruses and Insights into Cancer (Recent Results in Cancer Research)




  • Publisher:
  • Number Of Pages: 376
  • Publication Date: 29 Oct 2010
  • ISBN-10 / ASIN: 0387095802
  • ISBN-13 / EAN: 9780387095806
Product Description:

This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.

From the Back Cover
Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Contents
1 Overview of Retrovirology.................................................. .................... 1
Naomi Rosenberg
2 Mechanisms of Oncogenesis by Retroviruses........................................ 31
Karen L. Beemon and Mohan Bolisetty
3 Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses.................................................. .................... 53
Sandra K. Ruscetti and Joan L. Cmarik
4 Genetics of Host Resistance to Retroviruses and Cancer..................... 95
Chioma M. Okeoma and Susan R. Ross
5 Endogenous Retroviruses and Cancer.................................................. . 119
Jaquelin P. Dudley, Jennifer A. Mertz, Sanchita Bhadra, Massimo Palmarini, and Christine A. Kozak
6 Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer.............................................. 163
Matthew Kesic and Patrick L. Green
7 Cancers Induced by Piscine Retroviruses.............................................. 191
Sandra L. Quackenbush, James W. Casey, Paul R. Bowser,
and Joel Rovnak
8 The Immune Response to Oncogenic Retroviruses................................. 219
Melanie R. Rutkowski and William R. Green
9 Retrovirus-induced Immunodeficiency and Cancer............................. 259
Laura S. Levy
10 Retroviruses as Tools to Identify Oncogenes and Tumor Suppressor Genes.................................................. ............... 285
James C. Neil and Monica A. Stewart
11 Emerging Retroviruses and Cancer.................................................. ..... 307
Maribeth V. Eiden and Dwayne L. Taliaferro
Index.................................................. .................................................. .............. 335

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