NOTICE Notice: This is an old thread. The last post was 2353 days ago. If your post is not directly related to this discussion please consider making a new thread.
Results 1 to 3 of 3

Thread: Atopic Dermatitis in Dogs: Novel insights into mechanisms of disease

  1. #1
    LABRyeah's Avatar
    Silver Member


    Status
    Offline
    Join Date
    Aug 2009
    Work
    Veterinary Professor
    Country
    Peru
    Gender
    Male
    Total Posts
    156
    Rep Power
    1006
    Total thanks received
    8,133
    Thanks for this post
    208
    Veterinary Professor I'm from Peru

    Default Atopic Dermatitis in Dogs: Novel insights into mechanisms of disease

    Atopic Dermatitis in Dogs: Novel insights into mechanisms of disease





    Author: Schlotter, Y.M.
    Source: Diergeneeskunde proefschriften (2009)
    Publisher: Utrecht University
    Paperback: 192

    Abstract:

    Atopic dermatitis in dogs Novel insights into mechanisms of disease Atopic dermatitis in dogs is the most important canine pruritic disorder, described for the first time in 1971. It is defined as a genetically-predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features, associated with IgE antibodies specific for environmental allergens such as house dust mites and grass pollen. Atopic dermatitis in dogs harbors many similarities with its human counterpart such as the young age of onset, the clinical presentation and the genetic predisposition to develop the disease. Atopic dermatitis in human and dogs has been largely viewed as a disease of immunologic etiology. Key roles are played by dendritic cell signaling, the Th1/T2 cell dysregulation, IgE production, and mast cell hyperreactivity in the development of the pruritic inflammatory dermatosis. However, more recently it has been proposed that an intrinsic defect in the epithelial cell leads to a dysfunction in the epidermal barrier followed by immune system activation. In this thesis major research questions addressed, concern the role of fatty acids and their metabolic enzymes in the inflammation in canine atopic dermatitis and their possible modulatory effect. In addition, we have characterized the immunologic phenotype of atopic skin, particularly at the level of mRNA expression. It is concluded that spontaneous atopic dogs show a mixed Th1/Th2 inflammatory pattern which is consistent with human findings. In addition, it was found that lesional skin of atopic dogs contains a significant higher amount of arachidonic acid, which metabolism results primarily in inflammatory metabolites, the 2-series prostaglandins and the 4-series leukotrienes. This likely contributes to the inflammatory reaction seen in lesional skin. A question for future research is how the arachidonic content in lesional skin becomes this high. Several explanations for this high arachidonic acid content are discussed, whereas one of these have been addressed in this thesis and concern the cell infiltrates in lesional atopic skin. As atopic skin inhabits increased amounts of inflammatory cells and as arachidonic acid is the main fatty acid in the membranes of these cells, this might explain our finding of the high amount of AA in lesional skin. It is further reasoned that these cell infiltrates in lesional (and non-lesional) skin explain the high levels found for 5-lipoxygenase, 5-lipoxygenase-activating protein, leukotriene A4 hydrolase and microsomal prostaglandin-E synthase. These observations support future therapies with anti-leukotriene drugs in atopic dogs. It is very likely that in dogs, as in human, an epidermal barrier dysfunction together with an immunologic disturbance leads to atopic dermatitis; however it is not yet known which of these two systems initiate disease development. Based on the currently known similarities between human and canine atopic dermatitis now supplemented with our findings, there is strong evidence that the dog might serve as a good model for further research into human atopic dermatitis as well.


    Link:
    Hidden contents (Our Amazon affiliate links)
    You must click 'Thank You' before you can see the data contained here. You can purchase this item from Amazon with discount through our amazon affiliate link.
    BUT You DONOT have sufficient rights to see the hidden data contained here.
    Please Register to see contents.
    Reply With Quote Reply With Quote
    Thanks

  2. Who Said Thanks:

    There are too many to display.

  3. #2
    Guillermo87's Avatar
    New Member

    Status
    Offline
    Join Date
    Nov 2010
    Work
    Pre-Veterinary
    Country
    Argentina
    Gender
    Male
    Total Posts
    4
    Rep Power
    0
    Total thanks received
    9
    Thanks for this post
    5
    Pre-Veterinary I'm from Argentina

    Default

    Have u already read it?. Hope is interesting . Thanks!
    Reply With Quote Reply With Quote
    Thanks

  4. Who Said Thanks:


  5. #3
    Motoko's Avatar
    VETeLiB Administrator

    Status
    Offline
    Join Date
    Jan 2010
    Work
    Small Animals Practice
    Country
    Venezuela
    Gender
    Female
    Total Posts
    6,041
    Rep Power
    10
    Total thanks received
    784,465
    Thanks for this post
    78
    Small Animals Practice I'm from Venezuela

    Default

    Treatment of Canine Atopic Dermatitis
    by Yvette Mariska Schlotter, 1971.
    Thesis. University of Utrecht, Netherlands.
    Alternative Links:
    Multiple 11 MB
    DF - RS - MU - ZS - Easy Share - MediaFire - FileServe - FF - HF - Filesonic - ifile.it - x7.to - Wupload - Oron

    Hidden contents (Our Amazon affiliate links)
    You must click 'Thank You' before you can see the data contained here. You can purchase this item from Amazon with discount through our amazon affiliate link.
    BUT You DONOT have sufficient rights to see the hidden data contained here.
    Please Register to see contents.

    Updated Links 4/11/11
    Last edited by Motoko; 5th November 2011 at 03:20 AM. Reason: ADD MULTIPLE UPDATED LINKS.
    Reply With Quote Reply With Quote
    Thanks

Similar Threads

  1. Treatment of canine atopic dermatitis
    By chocolate chip in forum Small Animals (Pets) eBooks
    Replies: 1
    Last Post: 5th July 2011, 12:54 AM
  2. Atopic Dermatitis: When only scratching seems to help
    By super boi in forum Veterinary Audios
    Replies: 0
    Last Post: 15th March 2010, 04:09 PM
  3. Malassezia and canine atopic dermatitis
    By peruk in forum Lectures & Courses
    Replies: 0
    Last Post: 11th March 2010, 10:59 PM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •