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Thread: Lehninger Principles of Biochemistry 5th Edition

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    Default Lehninger Principles of Biochemistry 5th Edition

    Lehninger Principles of Biochemistry 5th Edition
    by David L. Nelson, Michael M. Cox

    Pub. Date: February 2008
    Publisher: Freeman, W. H. & Company
    ISBN-13: 9780716771081
    ISBN: 071677108X
    Edition Description: Fifth Edition

    Lehninger Principles of Biochemistry, Fourth Edition brings clarity and coherence to an often unwieldy discipline, while incorporating the field's most important recent developments and applications.This comprehensive biochemical text covers all aspects of modern biochemistry, together with many new developments since the previous edition of four years ago.The target audience includes senior undergraduate, graduate, and medical students. The authors are both knowledgeable and experienced.Features: There are several comprehensive biochemistry texts available. The fourth edition of Lehninger draws on a successful history initiated with the first edition which was a landmark text in its time. The 28 chapters follow an expected and logical progression from discussion of the fundamental molecules involved in cellular events through metabolism to the latest aspects of molecular biology. Illustrations are well done and frequent. Each chapter is accompanied by a short but useful bibliography and a set of problems. Problem answers are at the end, together with a detailed glossary and a thorough index. In an attempt to capture as broad a student audience as possible, discussions of both photosynthesis and metabolic diseases are offered. Thus, the material can be used in undergraduate/graduate courses as well as in medical school. As with other representatives of this text style, the typical student is likely to have some difficulty assigning relative importance to a given item considering the overall depth of coverage of topics. Nevertheless, careful reading with some guidance will be rewarding for most scholars and the book will serve as companion text for the usual biochemistry course. The bibliography is not as complete as some, but will provide pointers to additional material. A useful, albeit formidable (for the student) contribution.

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    1 The Foundations of Biochemistry
    1.1 Cellular Foundations
    1.2 Chemical Foundations
    1.3 Physical Foundations
    1.4 Genetic Foundations
    1.5 Evolutionary Foundations
    Box 1–1 Molecular Weight, Molecular Mass, and Their Correct Units
    Box 1–2 Louis Pasteur and Optical Activity: In Vino, Veritas
    Box 1–3 Entropy: The Advantages of Being Disorganized
    • Now introduces the concepts of proteomes and proteomics
    • Updated section on how a new species evolves
    • Increased emphasis on the interdependence of life forms in global cycles of energy

    2 Water
    2.1 Weak Interactions in Aqueous Systems
    2.2 Ionization of Water, Weak Acids, and Weak Bases
    2.3 Buffering against pH Changes in Biological Systems
    2.4 Water as a Reactant
    2.5 The Fitness of the Aqueous Environment for Living Organisms
    Box 2–1 Medicine: On Being One’s Own Rabbit (Don’t Try This at Home!)
    • Expanded discussion of blood pH buffering by the bicarbonate system,including a new box describing Haldane’s use of himself as a guinea pig in experiments aimed at changing the acidity of blood
    • New section on ketoacidosis in diabetes

    3 Amino Acids, Peptides, and Proteins
    3.1 Amino Acids
    3.2 Peptides and Proteins
    3.3 Working with Proteins
    3.4 The Structure of Proteins: Primary Structure
    Box 3–1 Methods: Absorption of Light by Molecules: The Lambert-Beer Law
    Box 3–2 Methods: Investigating Proteins with Mass Spectrometry
    Box 3–3 Medicine: Consensus Sequences and Sequence Logos
    • Significant revision to bioinformatics
    • More thorough explanation of consensus sequences, including an illustration of common ways to depict consensus sequences

    4 The Three-Dimensional Structure of Proteins
    4.1 Overview of Protein Structure
    4.2 Protein Secondary Structure
    4.3 Protein Tertiary and Quaternary Structures
    4.4 Protein Denaturation and Folding
    Box 4–1 Methods: Knowing the Right Hand from the Left
    Box 4–2 Permanent Waving Is Biochemical Engineering
    Box 4–3 Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables
    Box 4–4 The Protein Data Bank
    Box 4–5 Methods: Methods for Determining the Three-Dimensional Structure of a Protein
    Box 4–6 Medicine: Death by Misfolding: The Prion Diseases
    • New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases
    • New section on circular dichroism

    5 Protein Function
    5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
    5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
    5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
    Box 5–1 Medicine: Carbon Monoxide: A Stealthy Killer

    6 Enzymes
    6.1 An Introduction to Enzymes
    6.2 How Enzymes Work
    6.3 Enzyme Kinetics as an Approach to Understanding Mechanism
    6.4 Examples of Enzymatic Reactions
    6.5 Regulatory Enzymes
    Box 6–1 Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot
    Box 6–2 Kinetic Tests for Determining Inhibition Mechanisms
    Box 6–3 Evidence for Enzyme–Transition State Complementarity
    • More explanatory text added to the mechanisms for the enolase and lysozyme reactions
    • New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples

    7 Carbohydrates and Glycobiology
    7.1 Monosaccharides and Disaccharides
    7.2 Polysaccharides
    7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids
    7.4 Carbohydrates as Informational Molecules: The Sugar Code
    7.5 Working with Carbohydrates
    Box 7–1 Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes
    • New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes
    • New section on sugar analogs as drugs that target viral neuraminidase
    • Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS

    8 Nucleotides and Nucleic Acids
    8.1 Some Basics
    8.2 Nucleic Acid Structure
    8.3 Nucleic Acid Chemistry
    8.4 Other Functions of Nucleotides

    9 DNA-Based Information Technologies
    9.1 DNA Cloning: The Basics
    9.2 From Genes to Genomes
    9.3 From Genomes to Proteomes
    9.4 Genome Alterations and New Products of Biotechnology
    Box 9–1 Medicine: A Potent Weapon in Forensic Medicine
    Box 9–2 Medicine: The Human Genome and Human Gene Therapy
    • New material on the green fluorescent protein
    • Thorough updating of genomics section

    10 Lipids
    10.1 Storage Lipids
    10.2 Structural Lipids in Membranes
    10.3 Lipids as Signals, Cofactors, and Pigments
    10.4 Working with Lipids
    Box 10–1 Sperm Whales: Fatheads of the Deep
    Box 10–2 Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases
    • New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease
    • New section on lipidomics
    • New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods

    11 Biological Membranes and Transport
    11.1 The Composition and Architecture of Membranes
    11.2 Membrane Dynamics
    11.3 Solute Transport across Membranes
    Box 11–1 Methods: Atomic Force Microscopy to Visualize Membrane Proteins
    Box 11–2 Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes
    Box 11–3 Medicine: A Defective Ion Channel in Cystic Fibrosis
    • Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry
    • Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids
    • New information on the structural basis for voltage gating in a K+ channel

    12 Biosignaling
    12.1 General Features of Signal Transduction
    12.2 G Protein–Coupled Receptors and Second Messengers
    12.3 Receptor Tyrosine Kinases
    12.4 Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
    12.5 Multivalent Scaffold Proteins and Membrane Rafts
    12.6 Gated Ion Channels
    12.7 Integrins: Bidirectional Cell Adhesion Receptors
    12.8 Regulation of Transcription by Steroid Hormones
    12.9 Signaling in Microorganisms and Plants
    12.10 Sensory Transduction in Vision, Olfaction, and Gustation
    12.11 Regulation of the Cell Cycle by Protein Kinases
    12.12 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
    Box 12–1 Methods: Scatchard Analysis Quantifies the Receptor-Ligand Interaction
    Box 12–2 Medicine: G Proteins: Binary Switches in Health and Disease
    Box 12–3 Methods: FRET: Biochemistry Visualized in a Living Cell
    Box 12–4 Medicine: Color Blindness: John Dalton’s Experiment from the Grave
    Box 12–5 Medicine: Development of Protein Kinase Inhibitors for Cancer Treatment
    • New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs
    • New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function
    • Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+
    • New medical box on the use of protein kinase inhibitors in cancertherapy

    13 Bioenergetics and Biochemical Reaction Types

    13.1 Bioenergetics and Thermodynamics
    13.2 Chemical Logic and Common Biochemical Reactions
    13.3 Phosphoryl Group Transfers and ATP
    13.4 Biological Oxidation-Reduction Reactions
    Box 13–1 Firefly Flashes: Glowing Reports of ATP
    • New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types

    14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
    14.1 Glycolysis
    14.2 Feeder Pathways for Glycolysis
    14.3 Fates of Pyruvate under Anaerobic Conditions: Fermentation
    14.4 Gluconeogenesis
    14.5 Pentose Phosphate Pathway of Glucose Oxidation
    Box 14–1 Medicine: High Rate of Glycolysis in Tumors Suggests Targets for Chemotherapy and Facilitates Diagnosis
    Box 14–2 Athletes, Alligators, and Coelacanths: Glycolysis at Limiting Concentrations of Oxygen
    Box 14–3 Ethanol Fermentations: Brewing Beer and Producing Biofuels
    Box 14–4 Medicine: Why Pythagoras Wouldn’t Eat Falafel: Glucose 6-Phosphate Dehydrogenase Deficiency
    • New medical box on glucose uptake deficiency in type 1 diabetes
    • New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment

    15 Principles of Metabolic Regulation
    15.1 Regulation of Metabolic Pathways
    15.2 Analysis of Metabolic Control
    15.3 Coordinated Regulation of Glycolysis and Gluconeogenesis
    15.4 The Metabolism of Glycogen in Animals
    15.5 Coordinated Regulation of Glycogen Synthesis and Breakdown
    Box 15–1 Methods: Metabolic Control Analysis: Quantitative Aspects
    Box 15–2 Isozymes: Different Proteins That Catalyze the Same Reaction
    Box 15–3 Medicine: Genetic Mutations That Lead to Rare Forms of Diabetes
    Box 15–4 Carl and Gerty Cori: Pioneers in Glycogen Metabolism and Disease
    • New section on emerging role of ribulose 5-phosphate as central regulator of glycolysis and gluconeogenesis
    • Expanded discussion of phosphoprotein phosphatases in metabolic regulation
    • Expanded coverage of the role of transcriptional regulators in metabolic regulation
    • New medical box on mutations that lead to rare forms of diabetes regulation (MODY)

    16 The Citric Acid Cycle
    16.1 Production of Acetyl-CoA (Activated Acetate)
    16.2 Reactions of the Citric Acid Cycle
    16.3 Regulation of the Citric Acid Cycle
    16.4 The Glyoxylate Cycle
    Box 16–1 Moonlighting Enzymes: Proteins with More Than One Job
    Box 16–2 Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing!
    Box 16–3 Citrate: A Symmetric Molecule That Reacts Asymmetrically
    Box 16–4 Citrate Synthase, Soda Pop, and the World Food Supply
    • New box on effect of diabetes on the citric acid cycle and ketone body formation
    • Expanded discussion of substrate channeling
    • New section on mutations in citric acid cycle that lead to cancer
    • New box on moonlighting enzymes

    17 Fatty Acid Catabolism
    17.1 Digestion, Mobilization, and Transport of Fats
    17.2 Oxidation of Fatty Acids
    17.3 Ketone Bodies
    Box 17–1 Fat Bears Carry Out b Oxidation in Their Sleep
    Box 17–2 Coenzyme B12: A Radical Solution to a Perplexing Problem
    • New section on the role of transcription factors (PPARs) in regulation of lipid catabolism

    18 Amino Acid Oxidation and the Production of Urea
    18.1 Metabolic Fates of Amino Groups
    18.2 Nitrogen Excretion and the Urea Cycle
    18.3 Pathways of Amino Acid Degradation
    Box 18–1 Medicine: Assays for Tissue Damage
    Box 18–2 Medicine: Scientific Sleuths Solve a Murder Mystery
    • New section on pernicious anemia and associated problems in strict vegetarians.

    19 Oxidative Phosphorylation and Photophosphorylation
    Oxidative Phosphorylation

    19.1 Electron-Transfer Reactions in Mitochondria
    19.2 ATP Synthesis
    19.3 Regulation of Oxidative Phosphorylation
    19.4 Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
    19.5 Mitochondrial Genes: Their Origin and the Effects of Mutations
    Photosynthesis: Harvesting Light Energy
    19.6 General Features of Photophosphorylation
    19.7 Light Absorption
    19.8 The Central Photochemical Event: Light-Driven Electron Flow
    19.9 ATP Synthesis by Photophosphorylation
    19.10 The Evolution of Oxygenic Photosynthesis
    Box 19–1 Hot, Stinking Plants and Alternative Respiratory Pathways
    • Updated discussion of the structure of the electron transfer complexes of mitochondria and chloroplasts, and of the Fo complex
    • Updated description of the water-splitting complex’s structure in chloroplasts
    • Expanded description of mitochondrial diseases and mitochondrial role in diabetes

    20 Carbohydrate Biosynthesis in Plants and Bacteria
    20.1 Photosynthetic Carbohydrate Synthesis
    20.2 Photorespiration and the C4 and CAM Pathways
    20.3 Biosynthesis of Starch and Sucrose
    20.4 Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
    20.5 Integration of Carbohydrate Metabolism in the Plant Cell

    21 Lipid Biosynthesis
    21.1 Biosynthesis of Fatty Acids and Eicosanoids
    21.2 Biosynthesis of Triacylglycerols
    21.3 Biosynthesis of Membrane Phospholipids
    21.4 Biosynthesis of Cholesterol, Steroids, and Isoprenoids
    Box 21–1 Mixed-Function Oxidases, Oxygenases, and Cytochrome P-450
    • Revised and updated section on fatty acid synthase includes new structural information on FAS I
    • Updated information on cyclooxygenase inhibitors (pain relievers Vioxx, Celebrex, Bextra)
    • New information on HMG-CoA reductase and new m
    edical box on statins

    22 Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
    22.1 Overview of Nitrogen Metabolism
    22.2 Biosynthesis of Amino Acids
    22.3 Molecules Derived from Amino Acids
    22.4 Biosynthesis and Degradation of Nucleotides
    Box 22–1 Unusual lifestyles of the obscure but abundant
    Box 22–2 Medicine: On Kings and Vampires
    Box 22–3 Medicine: Curing African Sleeping Sickness with a Biochemical Trojan Horse
    • Updated coverage of nitrogen cycle section includes a new box on anammox bacteria
    • New information on therapy for acute lymphoblastic leukemia
    • New information on folic acid deficiency

    23 Hormonal Regulation and Integration of Mammalian Metabolism
    23.1 Hormones: Diverse Structures for Diverse Functions
    23.2 Tissue-Specific Metabolism: The Division of Labor
    23.3 Hormonal Regulation of Fuel Metabolism
    23.4 Obesity and the Regulation of Body Mass
    23.5 Obesity, the Metabolic Syndrome, and Type 2 Diabetes
    Box 23–1 Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin
    • Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes
    • Updated discussion of the integration of fuel metabolism in fed and starved states in diabetes

    24 Genes and Chromosomes

    24.1 Chromosomal Elements
    24.2 DNA Supercoiling
    24.3 The Structure of Chromosomes
    Box 24–1 Medicine: Curing Disease by Inhibiting Topoisomerases
    Box 24–2 Medicine: Epigenetics, Nucleosome Structure, and Histone Variants
    • New material on histone modification, histone variants, and nucleosome deposition
    • New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax)
    • New box on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity

    25 DNA Metabolism
    25.1 DNA Replication
    25.2 DNA Repair
    25.3 DNA Recombination
    Box 25–1 Medicine: DNA Repair and Cancer
    • New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism

    26 RNA Metabolism
    26.1 DNA-Dependent Synthesis of RNA
    26.2 RNA Processing
    26.3 RNA-Dependent Synthesis of RNA and DNA
    Box 26–1 Methods: RNA Polymerase Leaves Its Footprint on a Promoter
    Box 26–2 Fighting AIDS with Inhibitors of HIV Reverse Transcriptase
    Box 26–3 Methods: The SELEX Method for Generating RNA Polymers with New Functions
    Box 26–4 An Expanding RNA Universe Filled with TUF RNAs
    • New section on the expanding roles of RNA in cells

    27 Protein Metabolism
    27.1 The Genetic Code
    27.2 Protein Synthesis
    27.3 Protein Targeting and Degradation
    Box 27–1 Exceptions That Prove the Rule: Natural Variations in the Genetic Code
    Box 27–2 From an RNA World to a Protein World
    Box 27–3 Natural and Unnatural Expansion of the Genetic Code
    Box 27–4 Induced Variation in the Genetic Code: Nonsense Suppression
    • Expanded section on protein synthesis coupled to the advances in ribosome structure
    • New information on the roles of RNA in protein biosynthesis

    28 Regulation of Gene Expression
    28.1 Principles of Gene Regulation
    28.2 Regulation of Gene Expression in Bacteria
    28.3 Regulation of Gene Expression in Eukaryotes
    Box 28–1 Of Fins, Wings, Beaks, and Things
    • New information about roles of RNA in gene regulation
    • New box on the connections between evolution and development

    Appendix A Common Abbreviations in the Biochemical Research Literature
    Appendix B Abbreviated Solutions to Problems
    Last edited by VetSam; 7th March 2011 at 08:19 PM. Reason: Added Book Cover and made it more presentable Dear VetAqua :-)
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    Thanks to dear VetSam for adding a book cover.

    I just left it out because somehow it does not fit to the provided volume (being white instead of dark) although ISBNīs are matching, so donīt be confused.
    My philosophy for communication:
    Always assume the best and friendliest interpretation of my words that you can, I have no reason to be a rude dude at all, except you force me to!

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    Default Re: Lehninger Principles of Biochemistry 5th Edition

    Lehninger Principles of Biochemistry
    2008, 5th. Edition.
    Updated 10/08/2013

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