Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researche
Animal Hematotoxicology
A Practical Guide for Toxicologists and Biomedical Researchers
by G. O. Evans
Pages: 224
Publisher: CRC
Edition: 2008
Language: English
ISBN: 978-1420080091
Description
Hematology data from in vivo toxicology studies remains one of the most
predictive measures for human risk, as the same measurements made in
pre-clinical toxicology studies can be made in early clinical trials.
Covering the three main blood cell types – erythrocytes, leukocytes and
thrombocytes, this work is designed to clarify topics for new entrants
to the fields of laboratory animal hematology and toxicology,
especially those topics where the rules for human hematology do not
always apply. An entire chapter is devoted to immunotoxicology, a
scientific discipline that is closely aligned with hematology.
The text also addresses pre-analytical and analytical variables that
affect animal studies, as these play a far more important part when
interpreting data in contrast to humans where many of these variables
can be well controlled or have less physiological effect. Information
has been collated from published papers, textbooks and unpublished
data: Readers are provided withkey references to encourage further study
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