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Thread: Plasma levels of heat shock protein 72 and β-endorphin as indicators of... (2010)

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    Default Plasma levels of heat shock protein 72 and β-endorphin as indicators of... (2010)

    Plasma levels of heat shock protein 72 (HSP72) and β-endorphin as indicators of stress, pain and prognosis in horses with colic/
    The Veterinary Journal, Volume 184, Issue 1, April 2010, Pages 100-104
    Kati E. Niinistö, Raija V. Korolainen, Marja R. Raekallio, Anna K. Mykkänen, Ninna M. Koho, Mirja O. Ruohoniemi, Juhani Leppäluoto, A. Reeta Pösö


    Abstract

    A prospective observational study was performed to evaluate whether the plasma concentration of heat shock protein 72 (HSP72) or β-endorphin is related to clinical signs, blood chemistry, or severity of pain of colic. Seventy-seven horses with colic and 15 clinically healthy controls studied. The horses were divided into four groups which reflected increasing severity of colic, from normal control horses to horses with mild, moderate and severe colic. Blood samples were collected before any treatment. Packed cell volume (PCV) and plasma HSP72, β-endorphin, cortisol, adrenocorticotropic hormone (ACTH) and lactate concentrations were measured.Plasma β-endorphin was related with severity of colic and survival, as well as with plasma cortisol, ACTH and lactate concentrations, heart rate, PCV and pain score. High plasma HSP72 concentration may indicate circulatory deficits, but was not associated with clinical signs of colic. Plasma lactate still seemed to be the most useful single prognostic parameter in horses with colic.


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    Last edited by Mirmur; 15th March 2010 at 11:21 AM. Reason: erasing something
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