Immunoblastic malignant lymphoma in dolphins: histologic,ultrastructural, and
immunohistochemical features

Neoplasia is uncommon in cetaceans.
19,24 In a recent review,

19
only 41 confirmable tumors were reported from cetaceans.
Organ systems most commonly involved were the
gastrointestinal tract (31%), skin (24%), and the female reproductive
tract (21%). Of these tumors, benign mesenchymal
neoplasms were most common (49%), followed by benign
epithelial neoplasms (38%), malignant epithelial neoplasms
(8%), and malignant mesenchymal neoplasms (5%).
Confirmable lymphoid and hematopoietic neoplasia in cetaceans
are rare. A prolymphocytic malignant lymphoma of
the spleen and mesenteric lymph nodes and eosinophilic leukemia
and leukemic lymphoma in the spleen, liver, lymph
nodes, and kidney have been described in Pacific white-sided
dolphins (
Lagenorhynchus obliquidens).21 Hodgkin’s disease
has been diagnosed in multiple lymph nodes of a fin whale
(
Balaenoptera physalus)32 and killer whale (Orcinus orca).35

Malignant lymphoma has been described in a beluga whale
(
Delphinapterus leucas),13 and, recently, myelogenous leukemia
was reported in a bottlenose dolphin (
Tursiops truncatus).

12
In this report, the histopathologic, ultrastructural,

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