THE EFFECTS OF MERCURIC CHLORIDE ON CULTURED ATLANTIC SPOTTED DOLPHIN (Stenella plagiodon) RENAL CELLS AND THE ROLE OF SELENIUM IN PROTECTION
(ABSTRACT)
Marine mammals are known for their low susceptibility to mercury toxicity, and it
was hypothesized that selenium may play a role in protection against mercury toxicity.
To gain insight into the mechanisms of the low susceptibility of cetaceans, we
investigated the
in vitro effects (1) of mercuric chloride (HgCl2) on the ultrastructure and
cell death of Atlantic spotted dolphin renal cells (Sp1K cells), (2) of HgCl
2 on the cell
proliferation and cell cycle status of Sp1K and Rhesus monkey renal cells (MK2), and (3)
of sodium selenite (Na
2SeO3) on cell proliferation and cell death of control and HgCl2-
treated Sp1K cells.

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