Guillermo Rodriguez
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Efferent-like roles of afferent neurons in the gut:Blood flow regulation and tissue protection
Autonomic Neuroscience: Basic and Clinical 125 (2006) 70 – 75
Authors: Peter Holzer
Pages: 6 Pages
Language: English
Format
DF
Size:180 Kb
Abstract
The maintenance of gastrointestinal mucosal integrity depends on the rapid alarm of protective mechanisms in the face of pending
injury. To this end, the gastric mucosa is innervated by intrinsic sensory neurons and two populations of extrinsic sensory neurons: vagal
and spinal afferents. Extrinsic afferent neurons constitute an emergency system that is called into operation when the gastrointestinal
mucosa is endangered by noxious chemicals. The function of these chemoceptive afferents can selectively be manipulated and explored
with the use of capsaicin which acts via a cation channel termed TRPV1. Many of the homeostatic actions of spinal afferents are brought
about by transmitter release from their peripheral endings. When stimulated by noxious chemicals, these afferents enhance gastrointestinal
blood flow and activate hyperaemia-dependent and hyperaemia-independent mechanisms of protection and repair. In the rodent foregut
these local regulatory roles of sensory neurons are mediated by calcitonin gene-related peptide and nitric oxide. The pathophysiological
potential of the neural emergency system is best portrayed by the gastric hyperaemic response to acid back-diffusion, which is governed
by spinal afferent nerve fibres. This mechanism limits damage to the surface of the mucosa and creates favourable conditions for rapid
restitution and healing of the wounded mucosa.
[PDF]MEGA,PDF; https://mega.co.nz/#!RdsiBbAQ PASS:QeWJhmvtbadXjV1wvsfnZWr52zInwcpePjeu4eRF3NU [/PDF]
Autonomic Neuroscience: Basic and Clinical 125 (2006) 70 – 75
Authors: Peter Holzer
Pages: 6 Pages
Language: English
Format

Size:180 Kb
Abstract
The maintenance of gastrointestinal mucosal integrity depends on the rapid alarm of protective mechanisms in the face of pending
injury. To this end, the gastric mucosa is innervated by intrinsic sensory neurons and two populations of extrinsic sensory neurons: vagal
and spinal afferents. Extrinsic afferent neurons constitute an emergency system that is called into operation when the gastrointestinal
mucosa is endangered by noxious chemicals. The function of these chemoceptive afferents can selectively be manipulated and explored
with the use of capsaicin which acts via a cation channel termed TRPV1. Many of the homeostatic actions of spinal afferents are brought
about by transmitter release from their peripheral endings. When stimulated by noxious chemicals, these afferents enhance gastrointestinal
blood flow and activate hyperaemia-dependent and hyperaemia-independent mechanisms of protection and repair. In the rodent foregut
these local regulatory roles of sensory neurons are mediated by calcitonin gene-related peptide and nitric oxide. The pathophysiological
potential of the neural emergency system is best portrayed by the gastric hyperaemic response to acid back-diffusion, which is governed
by spinal afferent nerve fibres. This mechanism limits damage to the surface of the mucosa and creates favourable conditions for rapid
restitution and healing of the wounded mucosa.
[PDF]MEGA,PDF; https://mega.co.nz/#!RdsiBbAQ PASS:QeWJhmvtbadXjV1wvsfnZWr52zInwcpePjeu4eRF3NU [/PDF]