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EXERCISE TRAINING MODULATES APOPTOTIC SIGNALING IN THE AGING RAT HEART
HYO BUM KWAK
ABSTRACT
Exercise Training Modulates Apoptotic Signaling
in the Aging Rat Heart. (August 2004)
Hyo Bum Kwak, B.Ed., Seoul National University;
M.Ed., Seoul National University
Chair of Advisory Committee: Dr. John M. Lawler
Aging is characterized by a progressive decline in cardiac function. A critical
contributor to the age-related impairment in heart function is the loss of cardiac
myocytes through “apoptosis”, or programmed cell death. A dramatic increase in the rate
of apoptosis has been reported with aging in the rat left ventricle. In contrast, exercise
training not only improves cardiac function, but also reduces the risk of heart disease.
However, the ability of exercise training to modulate apoptotic signaling and apoptosis
in the aging heart remains unknown. Therefore, the purpose of this study was to
determine the effects of exercise training on apoptotic signaling and apoptosis in the
aging heart. We hypothesized that (1) aging would increase pro-apoptotic signaling and
apoptosis in the rat left ventricle, and (2) exercise training would ameliorate upregulation
of Bcl-2 family-driven apoptosis in the heart. Four and 25 month old Fischer-344 rats
were assigned to four groups: young control (YC), young trained (YT), old control (OC),
and old trained (OT). Exercise training groups ran on a treadmill for 60 min/day at 15
m/min (15° incline), 5 d/wk for 12 wk. Protein expression of Bax, Bcl-2, caspase-9, and
cleaved caspase-3 was measured using Western immunoblot analysis.
Pages:42
HYO BUM KWAK
ABSTRACT
Exercise Training Modulates Apoptotic Signaling
in the Aging Rat Heart. (August 2004)
Hyo Bum Kwak, B.Ed., Seoul National University;
M.Ed., Seoul National University
Chair of Advisory Committee: Dr. John M. Lawler
Aging is characterized by a progressive decline in cardiac function. A critical
contributor to the age-related impairment in heart function is the loss of cardiac
myocytes through “apoptosis”, or programmed cell death. A dramatic increase in the rate
of apoptosis has been reported with aging in the rat left ventricle. In contrast, exercise
training not only improves cardiac function, but also reduces the risk of heart disease.
However, the ability of exercise training to modulate apoptotic signaling and apoptosis
in the aging heart remains unknown. Therefore, the purpose of this study was to
determine the effects of exercise training on apoptotic signaling and apoptosis in the
aging heart. We hypothesized that (1) aging would increase pro-apoptotic signaling and
apoptosis in the rat left ventricle, and (2) exercise training would ameliorate upregulation
of Bcl-2 family-driven apoptosis in the heart. Four and 25 month old Fischer-344 rats
were assigned to four groups: young control (YC), young trained (YT), old control (OC),
and old trained (OT). Exercise training groups ran on a treadmill for 60 min/day at 15
m/min (15° incline), 5 d/wk for 12 wk. Protein expression of Bax, Bcl-2, caspase-9, and
cleaved caspase-3 was measured using Western immunoblot analysis.
Pages:42
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