• Hello Guest,
    We are experiencing difficulties in sending emails. It related to our platform and how it handles the requests. We are working on it. For now, we are using manual methods in sending emails. Please check your SPAM folder as well. Please let me know if you're still experiencing any issue? Use the Contact US at the bottom of the page to reach out.

    Best regards,
    VETeLiB Admin

Mouse Models for Cancer Stem Cell Research

pathvet

Member
Joined
Aug 13, 2013
Messages
65
Reaction score
72
Points
18
China Veterinary Student
Mouse Models for Cancer Stem Cell Research
by LE CHENG, ANIRUDH V. RAMESH, ANDREA FLESKEN-NIKITIN, JINHYANG CHOI, AND ALEXANDER YU. NIKITIN
Toxicologic Pathology, 2010, 38: 62-71
Abstract:
The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor
initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer
stem cells represent an appealing target for development of more selective and efficient therapies. However, direct testing of the cancer stem cell
concept and assessment of its therapeutic implications in human cancers have been complicated by the use of immunocompromised mice.
Genetically defined immunocompetent autochthonous mouse models of human cancer provide a valuable tool to address this problem. Furthermore,
they allow for a better understanding of the relevance of mechanisms controlling normal stem cell compartment to carcinogenesis. Advantages and
disadvantages of some of the existing mouse models are reviewed, and future challenges in cancer stem cell research are outlined.
 
Back
Top