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Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System

pathvet

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Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System
by
DIANNE CREASY, AXEL BUBE, EVELINE DE RIJK, HITOSHI KANDORI, MAKI KUWAHARA, REGIS MASSON, THOMAS NOLTE, RACHEL REAMS, KAREN REGAN, SABINE REHM, PETRINA ROGERSON, AND KATHARINE WHITNEY
Toxicologic Pathology, 2012, 40: 40S-121S
Abstract:

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of
the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an
internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to
provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of
laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document
is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases
from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions
induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive
system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a
common language to increase and enrich international exchanges of information among toxicologists and pathologists.
 
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