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Recommendations for Routine Sampling, Trimming, and Paraffin-Embedding of Female Reproduct

pathvet

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Recommendations for Routine Sampling, Trimming, and Paraffin-Embedding of Female Reproductive Organs, Mammary Gland, and Placenta in the Cynomolgus Monkey
by ERIC VAN ESCH, EVELINE P.C.T. DE RIJK, EBERHARD BUSE, MARTINA ZÖLLER, AND J. MARK CLINE
Toxicologic Pathology, 2008, 36: 164S-170S
Abstract:
In toxicity studies, the nonhuman primate is often the species of choice to evaluate the toxicologic potential of chemicals and drugs. Especially in
the case of effects on female reproductive organs and mammary glands, other animal species are less predictive for man. To enable reliable histopathologic
interpretation allowing a solid safety assessment, it is a prerequisite to obtain material of consistently high quality. Standardization of autopsy
techniques, tissue sampling, and fixation and staining procedures will help significantly to obtain the quality that is needed. For this purpose, a detailed
description of the procedures from necropsy to microscopic slide preparation of the female reproductive organs of the cynomolgus monkey is
given. Procedures to sample and process the placenta are included. These recommendations can be used to achieve consistent, high-quality tissue
preparations, allowing pathologists to conduct sensitive, accurate, and meaningful evaluations of the study material.
 
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