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New member
Oct 2, 2010
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Singapore Veterinary Student
Good day! I've searched the web for alflaxalone and its effect on liver diseased patients but to no avail. Any help would be appreciated. Can alflaxalone be administered in patients with severe liver dysfunction? Thanks.
Alfaxalone (INN, also known as alphaxalone or alphaxolone) is a neurosteroidgeneral anaesthetic. It is one of the constituents of althesin. It is used in veterinary practice under the tradename Alfaxan. It is licensed for use in both dogs and cats. Unlike some of its predecessors Alfaxalone is not associated with histamine release and anaphylaxis. The primary mechanism for the anaesthetic action of alfaxalone is modulation of neuronal cell membrane chloride ion transport (1), induced by binding of alfaxalone to GABAA cell surface receptors. It has also been shown that Alfaxalone binds to a different region of this receptor than the benzodiazipines (2). Alfaxalone is metabolised rapidly in the liver. Alfaxalone has a very short plasma elimination half-life in dogs and cats.


Here a rapid guide about the drug in VASG

Rapidly metabolised in the liver... it should or not be a bad thing for the liver... let's start a Brain Storm here.

Hope you enjoy

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And you can always use Inhalant anesthesia dude... Isoflurane and Sevoflurane > lungs working...with care in patients with shock, inhalant anesthesia is a friend of the liver.
I suppose alfaxalone is more of an induction drug. And yes isoflurane is definitely a first choice maintenance drug.